[CHEMISTRY] GC DERIVATIVES

[che313]

WHERE CAN I FIND THE CHEMISTRY INFORMATION ABOUT GC DERIVATIVES? I.E. THE STRUCTURE OF PFPA, HFBA, MSTFA, BSTFA, ETC AND THIERE REACTIONS WITH COULMS STATIONARY PHASE

[DR]

Search vendors of GCs and associated chemicals. There are plenty of applications and descriptions of their chemicals (may have to look at MSDSs for structures, formula weights).

Agilent,
Phenomenex,
Sigma/Aldrich,
Pierce etc. etc. etc.

[sassman]

There is a lot of information here:

http://www.sigmaaldrich.com/etc/mediali ... p/4537.pdf

As for reactions with the column stationary phase, you probably will not find that information online. There are a couple of books on derivatization reagents and reactions that would have more info, check Amazon.

[HW Mueller]

You are thinking of interactions with the stat. phase? You wouldn´t want reactions.
There are books on derivatization, I don´t have a ref. right here, but these should be easy to find, if I remember correctly there are some refs in this forum.

[tpmcginnis]

In general if you use derivatization methods that produce nonpolar derivatives, you will have good peak shapes and less interactions with nonpolar column phases. For example, if you prepare trimethylsilyl derivatives, phases such as DB-1 or DB-5 tend to work well. Silyl ethers or silyl esters sometimes do not have good peak shapes on some polar columns such as DB-Wax (polyethylene glycol type).
When analyzing silyl ether or ester derivatives, it is also to good to minimize active sites on the column, etc., as much as possible. Things such as connectors between retention gaps and columns can lead to active silica being exposed which can cause the derivatives to degrade.