Does anyone have any experience with trapping of polyethylene glycols with phenylboronic acid SPE columns?

It would seem to me that the glycols would be removed by forming cyclic esters with the boronic acid and, under the right conditions, nothing else would be impacted.

This should be easy to use on neutral or acidic compounds, but I am not sure if special conditions would be required to prevent binding for basic pharmaceuticals.

I would appreicate any guidance from anyone that might have tried this or has a protocol for binding of glycols that I can try and see if it works with our PEG samples.

Any information on potential porblems you might see with this idea would also be appreciated.

Cleaning up the samples to make cleaner HPLC injection and eliminate some placebo interferences seems well worth passing the sample through an SPE that removes only one thing.

Thanks for any suggestions that you might provide.