ECD relative sensitivity

[AICMM]

Does anyone have a reference that discusses relative sensitivity of ECD's to a wide range of compounds? In PID you can use the ionization potential and get a good handle on how sensitive the application will be. ECD's are much less clear cut but I am wondering if anyone has seen a publication that discusses this question. For example, nitro compounds, sulfur compounds, amines, dienes, etc, etc,.... This would really help me in discussing potential detection limits and when to applicate with an ECD versus an AID versus an FID, etc....

Best regards.

[krickos]

Hi
mayby a late comment, been travelling a bit and such

Anyways hard to find something good on the net here and the things I have is mainly based on the older ECD ie not newer mikroECD, even do things like range differ between the various ECD the following should give you an idea.

From "Chromatography Today" by Poole and Poole (ISBN 0-444-88492-0 or 0-444-891-89161-7):

Compound and realative response:
CF3CF2CF3 1,0
CF3Cl 3,3
CF2=CFCl 100
more examples are given.

But to generalize more the following is taken from an old Training book I received during training around 1996 at "old" HP:

Hydrocarbons 1
Esters, ethers 10
Alcoholsm ketones
mono-Cl/F, amines 100
Mono-Br, di Cl/F 1000
Anhydrines, tri-Cl 10000
Mono-I, di-Br, poly Cl/F 100 000
Di-I, tri-Br, poly Cl/F 1 000 000


Cheers

[AICMM]

Krickos,

Thanks for the reply. I will see if I can get the Chromatography Today article. I have similar if not same HP book. Problem is, I am interested in other compounds like mercaptans, disulfides, diols, dienes, etc, etc... which are not listed and which might be good candidates for ECD. For example, I know CS2 gives a bang up response but what about COS or H2S?

Thanks again.

Best regards.

[krickos]

Ahh OK

Now had it been a TCD...

I am afraid the book references will not help you with your compunds of intrest.

Have nothing and found nothing with regard to your compunds. There might be a few articles on Inorganic gas chromatography but I seem to have some acess issues with those, sorry no references.

In theory COS and H2S and conjugated double bounds should give some respons but would not dare to guess.

Good luck hunting