Advertisement

acetic acid and peroxyacetic acid

Discussions about HPLC, CE, TLC, SFC, and other "liquid phase" separation techniques.

2 posts Page 1 of 1
Does anyone forsee me having any problems analyzing peroxyacetic acid (pKa = 8.2) along with acetic acid on a C18 column with acidic phosphate eluent?
Randy
Dig for gold on the Moon...

Why don't you consider IC, HILIC or even ion-pairing techniques?

However, at an (at least slightly) acidic pH and with a sensitive detector a C18 column may do. The questions is if you get sufficient selectivity?



I bet there are Application Notes available from other suppliers. ZIC®-HILIC has proved to be useful for carboxylic acids, see http://www.sequant.com/sn/ufiles/SeQuan ... 00-13A.pdf
------------------------
Merck SeQuant AB
http://www.sequant.com
2 posts Page 1 of 1

Who is online

In total there are 29 users online :: 0 registered, 0 hidden and 29 guests (based on users active over the past 5 minutes)
Most users ever online was 11462 on Mon Dec 08, 2025 9:32 pm

Users browsing this forum: No registered users and 29 guests

Latest Blog Posts from Separation Science

Separation Science offers free learning from the experts covering methods, applications, webinars, eSeminars, videos, tutorials for users of liquid chromatography, gas chromatography, mass spectrometry, sample preparation and related analytical techniques.

Subscribe to our eNewsletter with daily, weekly or monthly updates: Food & Beverage, Environmental, (Bio)Pharmaceutical, Bioclinical, Liquid Chromatography, Gas Chromatography and Mass Spectrometry.

Liquid Chromatography

Gas Chromatography

Mass Spectrometry