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Waters Alliance Dissolution-HPLC
Posted: Tue Dec 11, 2007 2:22 pm
by John
Does anyone have experience with either Hanson or Distek dissolution systems with a Waters HPLC direct autosampler? I'd like to get an idea of the reliability of these systems.
Posted: Wed Dec 12, 2007 5:33 pm
by LC_labrat
I have never used the direct autosampler. I believe it also uses the Alliance HT HPLC. We bought one several years ago in hope of adding the direct autosampler later. I found the HPLC to be troublesome. It either ran extremely well, or if the extra solvent line, which is constantly running, ever had a problem (ran dry) it would take a long time (several days) to get the system equilibrated again. We finally put on a 10L bottle of solvent.
Posted: Wed Dec 12, 2007 7:26 pm
by John
What is that extra solvent line for? Why did you not opt for the dissolution autosampler in the end?
J
Posted: Thu Dec 20, 2007 5:29 pm
by LC_labrat
The Alliance HT has additional wash and purge solvent lines. If I understand it correctly they continously flush the needle/injector, increasing the ability to make faster injections. We went with Varian baths and autosamplers instead. The autosampler uses HPLC vials and we just transfer them over to the LC.