Advertisement

critical mass

Discussions about HPLC, CE, TLC, SFC, and other "liquid phase" separation techniques.

4 posts Page 1 of 1
Please ,can somebody help me.What is the recomended minimum mass I can measure on my analytical balance if readability is 0.1mg ,0.01mg,0.001mg. Does somebody know any guide about that.Thank you in advance.

The USP general chapter <46> goes into this. Basically, you're "accurately weighing" if:

0.001>3(Stdev)/(mass weighed)
where Stdev is for n=10 weighings of a given standard mass.

So, using manufacturer provided "reproducibility" specs and assuming modest tares for weighing vessels:

Mettler AT261 is good down to 45mg even though it reads down to 5 places when set to read grams.

Sartorius M2P is good to 3mg though it reads 1/1000 mg.
Thanks,
DR
Image

You can go to the Sartorius site for a table of data on their current models, and an explanation of the USP equation given above by DR

http://www.balances.com/sartorius/minim ... eight.html

I couldn't find the equivalent information in a nice table on the Mettler site, but you can probably assume their models will have similar values.

You, or your calibration service, are supposed to determine the value for your balance in your environment.

Please keep having fun,

Bruce Hamilton

Thank you ,
it was very useful .
4 posts Page 1 of 1

Who is online

In total there are 21 users online :: 2 registered, 0 hidden and 19 guests (based on users active over the past 5 minutes)
Most users ever online was 4374 on Fri Oct 03, 2025 12:41 am

Users browsing this forum: Google [Bot], Majestic-12 [Bot] and 19 guests

Latest Blog Posts from Separation Science

Separation Science offers free learning from the experts covering methods, applications, webinars, eSeminars, videos, tutorials for users of liquid chromatography, gas chromatography, mass spectrometry, sample preparation and related analytical techniques.

Subscribe to our eNewsletter with daily, weekly or monthly updates: Food & Beverage, Environmental, (Bio)Pharmaceutical, Bioclinical, Liquid Chromatography, Gas Chromatography and Mass Spectrometry.

Liquid Chromatography

Gas Chromatography

Mass Spectrometry