Chromatography Forum

Chromatography Forum is a public discussion group where you can post questions, news, or messages of interest to chromatographers everywhere, but you must be registered to participate (registration is FREE). If you are a registered user, please log in.
http://www.chromforum.org/

conditions for compound insoluble/unstable in water?

http://www.chromforum.org/viewtopic.php?t=6166

Page 1 of 1

Method validation

Posted: Fri May 25, 2007 12:33 am
by rohitdrl
dear all
I am looking to develop an hplc method for an ester prodrug of an antibiotic. it has a pKa of 8.4 and is basic in nature. It is not soluble in water (1%) and has stability problems in aqueous solution. Kindly suggest me solvents to dissolve the drug as well as mobile phase for performing HPLC (with photo diode array detector)

reply asap

Posted: Fri May 25, 2007 4:52 pm
by tom jupille
We're not mind-readers. Before we can suggest a solvent and conditions, it would help if you could tell us what it is soluble in!
All times are UTC
Page 1 of 1
Powered by phpBB® Forum Software © phpBB Limited
https://www.phpbb.com/