alfa bromo-2-chlorophenyl acetonitrile -hplc/gc method
Posted: Tue Jan 09, 2007 6:54 am
Please give suggestion for the method development by hplc and gc
GC Use a Supelcowax 10 capillary. Avoid using higher temperatures for injection and column as you can debrominate the molecule easily. Other option would be a Equity 1701 capillary.
Use toluene or acetonitrile as a dissolution solvent.
LC A simple C8 RPLC column, or an Ascentis Phenyl LC column where you can use normal or reverse phase mode might be a good starting point.
Rodney George
Senior Research and Development Scientist
Gas Separations Research
Supelco
595 North Harrison Road
Bellefonte, PA 16823
814-359-5737 voice
814-359-5459 fax
rgeorge@sial.com