alfa bromo-2-chlorophenyl acetonitrile -hplc/gc method

[M.Rameshkumar]

Please give suggestion for the method development by hplc and gc

[chromatographer1]

GC Use a Supelcowax 10 capillary. Avoid using higher temperatures for injection and column as you can debrominate the molecule easily. Other option would be a Equity 1701 capillary.

Use toluene or acetonitrile as a dissolution solvent.

LC A simple C8 RPLC column, or an Ascentis Phenyl LC column where you can use normal or reverse phase mode might be a good starting point.

Rodney George
Senior Research and Development Scientist
Gas Separations Research
Supelco
595 North Harrison Road
Bellefonte, PA 16823

814-359-5737 voice
814-359-5459 fax
rgeorge@sial.com