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Free acid content

Posted: Tue May 23, 2006 7:27 am
by nsreenivas
Could anybody suggest us a method for the quantification of Free acid left during the conversion of drugs into their corresponding sodium salts.

Posted: Tue May 23, 2006 4:54 pm
by tom jupille
Assuming you know the pKa of the drug, simply dissolve in water and measure the pH.