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Free acid content

Discussions about HPLC, CE, TLC, SFC, and other "liquid phase" separation techniques.

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Free acid content

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nsreenivas
Could anybody suggest us a method for the quantification of Free acid left during the conversion of drugs into their corresponding sodium salts.

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tom jupille
Site Admin
Assuming you know the pKa of the drug, simply dissolve in water and measure the pH.
-- Tom Jupille
LC Resources / Separation Science Associates
tjupille@lcresources.com
+ 1 (925) 297-5374
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