Bracketing Standard

[Sunjay]

Dear All,

As given in chapter on chromatography,USP recommedns to inject control standard preparation after suitable intrvals throughout the analysis run.

So my query is :
If the STP recommends to inject both resolution solution and standard solution (for area repeatibility), then which solution should be injected as the control preparation (or both of them should be injected) after suitable intervals.

Thanks

[vanjas]

I would suggest that standard solution be injected as a performance check for system consistent and our company do also.
That didn't make any problem at last FDA audit... [/url]

[Consumer Products Guy]

We do similar, inject the standard again at the end to demonstrate the the system was operating properly, no drift or changes.

[Sunjay]

Dear All

Thanks for your response.

So this means that the resolution solution and standard solution should be injected in beginning and for later interval only standard solution will be injected.

Thanx

[rc_12321]

No i do not agree with your views.With Whatever systemsuitability you started your system with that system suitability you have to bracket your analysis.