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Stability indicating method for Esteroids
Posted: Wed Sep 28, 2005 11:06 am
by Raj B
I am working on a combination product Ethinylestradiol and Levonorgestrel tablet Bp i have tried BP and USP method for same but it is not stability indicating for my combination any body have any idea about same pl help me
Raj B
Posted: Thu Sep 29, 2005 7:28 am
by Alex Buske
Please explain why it is not stability indicating. are peaks not separated?, do you pass the system suitability test?
Posted: Thu Sep 29, 2005 10:54 am
by Raj B
Please explain why it is not stability indicating. are peaks not separated?, do you pass the system suitability test?
System suitability is passing i got problem during force degredation their is to much interfarence of degradation product.
Thanks
Posted: Thu Sep 29, 2005 1:42 pm
by Alex Buske
You should try to fix the separation by some means. both EP and USP (maybe also BP) allow some variations in chromatography.