Stability indicating method for Esteroids

[Raj B]

I am working on a combination product Ethinylestradiol and Levonorgestrel tablet Bp i have tried BP and USP method for same but it is not stability indicating for my combination any body have any idea about same pl help me


Raj B

[Alex Buske]

Please explain why it is not stability indicating. are peaks not separated?, do you pass the system suitability test?

[Raj B]

Please explain why it is not stability indicating. are peaks not separated?, do you pass the system suitability test?

System suitability is passing i got problem during force degredation their is to much interfarence of degradation product.
Thanks

[Alex Buske]

You should try to fix the separation by some means. both EP and USP (maybe also BP) allow some variations in chromatography.