VETRANAL as quantitative standard for HPLC?

[artsjeroen]

Is anyone familiar with the VETRANAL analytical standards by FLUKA?
Are these standards useable as a quantitative standard for HPLC? Are they retraceable to USP/EP?

Or are these standards only suitable for FTIR, TLC, peak identification etc?

[HPLCaddict]

I'm not familiar with these VETRANAL standards, but Fluka (or Sigma-Aldrich - no wait, it's Merck, now, right?) actually has pharmaceutical secondary standards which can be used for quantitative analysis:

http://www.sigmaaldrich.com/analytical- ... ndary.html

They are traceable to USP/EP/BP. You'll get a comprehensive certificate for each batch of standard including all test results according to the pharmacopoeias.

[artsjeroen]

Thanks for the link! Those secondary standards might be quite useful at our laboratory.

The certificates that come with the VETRANAL standards specify an assay given in area%. So I guess they're not traceable to an other standard.
But area% has not really anything to do with the activity or purity of that standard. That's why I'm doubtful about the quantitative use of these standards.

[HAWEIR1989]

Hi everyone.

Does anyone knows the meaning of Vetranal grade for analytical standards?... can I used it for analytical quantitation.. do I have to certify it according to USP?...

I´m new in the bussiness so I would be very grateful for any help.

[HPLC chemist]

They cannot be used as primary standards (USP, EDQM, JP...), but they can be used as secondary standards if you have a suitable SOP. Typically, a standard is identified and characterized by MS, UV, NMR, FTIR... Thus, they should have an appropriate 'Certificate of Analysis (COA)'.

But there is no relevant guidance that I know of.