LC-QqQ comparision

[zemolo]

Hi!
We're planning to buy a new LC triple quad for routine analysis on textile and environmental samples.
We're considering four brands, and I wonder to know your opinion about this systems:
- AB Sciex QTrap 6500 (with Shimadzu Nexera UPLC)
- Agilent 6495 (with 1290 LC)
- Shimadzu 8050 (with Nexera UPLC)

Basing on the brochures, Shimadzu seems to be impressive (30000 amu/s, 555 MRM/s, polarity switch of 5ms) and it's also very cheap!
On the other hand, the most expensive AB Sciex has also the Ion Trap capability and the reputation to be very robust and to give results with excellent repeatability (and for reference, 20000amu/s, 500MRM/s, polarity switch of 20ms).

What are your opinion on these systems?

Thanks!

[Pepter]

Like in the order you list them.
1) AB Sciex
2) Agilent
3) Shimadzu

Its good to buy the instrument that is at least one year on market...

[dr_bahram1977]

I think in the same way.

If you think for long term( 10 year) robust instrument, it's AB Sciex.
If you think about easy setup, good service and plenty of document, it's Agilent.
If you're looking for cheap and good equipment, and ready to put it a said in 5 years, shimadzu could be the choice.

[zelda855]

Hello, can you tell us what you decided?
I think shimadzu is the best choice because has the best performances, the best UHPLC (nexera) and is much cheaper.
Why don't you also consider waters Xvo TQ-S and Thermo Orbitrap Q-Exactive?

[nbik]

Hello, can you tell us what you decided?
I think shimadzu is the best choice because has the best performances, the best UHPLC (nexera) and is much cheaper.
Why don't you also consider waters Xvo TQ-S and Thermo Orbitrap Q-Exactive?

What happened with the world?! When Shimadzu begin to be the best choice for mass-spectrometry?! The Apocalypse is coming
How can instrument with the lowest price be with the best performance? If specification is good, it doesn't mean it works good.)

To zemolo:
Take QQQ from ABSciex or Agilent and don't worry.

[zelda855]

In our lab we have:
Ab Sciex 5500
Agilent 6460
Agilent 6490
Shimadzu 8050
Waters Xevo TQD
Waters Xevo TQ-S

Absciex and Waters in my opinion are the best for the complete system (uhplc, mass spec, software, methods -ex. quanpedia is a very nice library -, etc).

Shimadzu 8050 is really a very nice surprise and is at the level of the other two instruments.

Agilent has good instruments but are of lower quality and less sensitive than the others.
6460 is much much less sensitive, 6490 have problems of contamination with "dirty" samples.

Hello, can you tell us what you decided?
I think shimadzu is the best choice because has the best performances, the best UHPLC (nexera) and is much cheaper.
Why don't you also consider waters Xvo TQ-S and Thermo Orbitrap Q-Exactive?

What happened with the world?! When Shimadzu begin to be the best choice for mass-spectrometry?! The Apocalypse is coming
How can instrument with the lowest price be with the best performance? If specification is good, it doesn't mean it works good.)

To zemolo:
Take QQQ from ABSciex or Agilent and don't worry.