mobile phase for soft drinks, sports drinks, juice by LC-MS

[dhdh]

Can anyone suggest a mobile phase and column for analyzing carbonated beverages, sports drinks, juices etc with LC-MS? I assume the sugars and organic acids elute very quickly by reverse phase. Ideally it would be a method that covers a lot of ingredients in a single run on a C18 column, even if the sugars and acids don't get fully resolved.
Years ago I analyzed carbonated beverages by HPLC on a C18 column for some common preservatives, artificial sweeteners and breakdown products. I haven't been able to do that for a long time, but may soon have a chance to get back into it. It would also be nice to analyze the weighting agents or emulsifiers (SAIB or ester gum in things like Gatorade).

[James_Ball]

Can anyone suggest a mobile phase and column for analyzing carbonated beverages, sports drinks, juices etc with LC-MS? I assume the sugars and organic acids elute very quickly by reverse phase. Ideally it would be a method that covers a lot of ingredients in a single run on a C18 column, even if the sugars and acids don't get fully resolved.
Years ago I analyzed carbonated beverages by HPLC on a C18 column for some common preservatives, artificial sweeteners and breakdown products. I haven't been able to do that for a long time, but may soon have a chance to get back into it. It would also be nice to analyze the weighting agents or emulsifiers (SAIB or ester gum in things like Gatorade).

Are you interested in things like Sodium Benzoate, Potassium Sorbate and Sodium Propionate? I have a method for those on LCMS that is rather simple, I would need to look up the exact conditions though.

[dhdh]

Can anyone suggest a mobile phase and column for analyzing carbonated beverages, sports drinks, juices etc with LC-MS? I assume the sugars and organic acids elute very quickly by reverse phase. Ideally it would be a method that covers a lot of ingredients in a single run on a C18 column, even if the sugars and acids don't get fully resolved.
Years ago I analyzed carbonated beverages by HPLC on a C18 column for some common preservatives, artificial sweeteners and breakdown products. I haven't been able to do that for a long time, but may soon have a chance to get back into it. It would also be nice to analyze the weighting agents or emulsifiers (SAIB or ester gum in things like Gatorade).

Are you interested in things like Sodium Benzoate, Potassium Sorbate and Sodium Propionate? I have a method for those on LCMS that is rather simple, I would need to look up the exact conditions though.

Yes, but also looking at other ingredients too. The main goal is to tell if something is wrong or 'out of whack' with the product (misformulation or breakdown or contamination) but also to find out what's in the drinks (phosphoric and/or citric acid, HFCS, caffeine, etc). In the early HPLC-UV method (right after NutraSweet became popular), benzoate was a very late eluter if I remember correctly. Back then the goal was to see if the aspartame had broken down yet.