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Imidazole-2-carboxaldehyde purity method

http://www.chromforum.org/viewtopic.php?t=24320

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Imidazole-2-carboxaldehyde purity method

Posted: Mon Feb 24, 2014 11:29 am
by malsobczak
Hi,
I need to develop purity method HPLC/GC for above compound.
The problem on HPLC is retention of that material
I 've tried reverse phase C18( retention on solvent front) low and high pH
Then I've tried hillic with the same lack of retention.


Thanks for any help in advance

M

Re: Imidazole-2-carboxaldehyde purity method

Posted: Mon Feb 24, 2014 2:12 pm
by Gerhard Kratz
Maybe this will provide some help:
http://www.atmos-chem-phys.net/12/6323/ ... 3-2012.pdf

Re: Imidazole-2-carboxaldehyde purity method

Posted: Mon Feb 24, 2014 5:41 pm
by Andy Alpert
This compound is polar enough that retention in HILIC shouldn't be a problem. Please supply the following details:

1) The column you're using.
2) The mobile phases
3) The composition of the solvent that the sample was in when injected.
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