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2,4-CFT isomer separation on GC

http://www.chromforum.org/viewtopic.php?t=23977

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2,4-CFT isomer separation on GC

Posted: Tue Dec 17, 2013 4:13 pm
by praveenpaliwal
Good Evening Experts,

I want to separate both of this isomers 2,4 CFT, (i.e 2-Chloro 4-Fluoro Toluene) and its isomer (4-Chloro,2 Fluoro Toluene) which condition or column is suitable for this????

Best regards

Praveen

Re: 2,4-CFT isomer separation on GC

Posted: Mon Jan 13, 2014 3:33 pm
by gcguy
The boiling points (3C difference) and polarity will be fairly similar so you might struggle. Probably best to start with a DB5 and then if that does not work try something more polar like a DB17.

Conditions would be typical method development..start at 50C then 20C per minute up to 300C with a 1ml flow an adapt from there.

I remember looking at similar compounds many years ago when working a chemist doing halex reactions. I think I was using a DB17 type column but then it was 25 years ago!

GCguy
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