2,4-CFT isomer separation on GC

[praveenpaliwal]

Good Evening Experts,

I want to separate both of this isomers 2,4 CFT, (i.e 2-Chloro 4-Fluoro Toluene) and its isomer (4-Chloro,2 Fluoro Toluene) which condition or column is suitable for this????

Best regards

Praveen

[gcguy]

The boiling points (3C difference) and polarity will be fairly similar so you might struggle. Probably best to start with a DB5 and then if that does not work try something more polar like a DB17.

Conditions would be typical method development..start at 50C then 20C per minute up to 300C with a 1ml flow an adapt from there.

I remember looking at similar compounds many years ago when working a chemist doing halex reactions. I think I was using a DB17 type column but then it was 25 years ago!

GCguy