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How improve SPME-GCMS sensitivity
Posted: Mon Aug 26, 2013 11:30 pm
by jiangds06
how do I improve from MS side?
Re: How improve SPME-GCMS sensitivity
Posted: Tue Aug 27, 2013 11:50 am
by LCbob
Hi
You could increase the EM voltage ( watch out for increased noise though ), run in SIM mode, play around with the tune parameters, use a lower bleed column perhaps, try different m/z ions.
Re: How improve SPME-GCMS sensitivity
Posted: Wed Aug 28, 2013 3:51 pm
by James_Ball
Make sure inlet temperature is high enough to desorb the target analyte but not too high to damage the coating on the fiber.
Also you may need to salt out your analyte if doing aqueous samples.