Ion Pairing Tetrabutylammonium Hydroxide

[Jing_Fan]

Hi,

We have a compound that analysed using tetrabutylammonium hydroxide. May i change tetrabutylammonium hydroxide with tetrabutylammonium hydrogen sulfate? What is the difference between tetrabutylammonium hydroxide and tetrabutylammonium hydrogen sulfate?

Best regards

[Markus Laeubli, Metrohm]

Assuming that your compound is an organic acid, building the ion-pair releases an OH- with hydroxide. This is neutralized by the H+ from the organic acid.
By using the hydrogen sulfate you are getting sulfuric acid instead. This migh interfere with the separation.

[Klaus I.]

Hi,

We have a compound that analysed using tetrabutylammonium hydroxide. May i change tetrabutylammonium hydroxide with tetrabutylammonium hydrogen sulfate? What is the difference between tetrabutylammonium hydroxide and tetrabutylammonium hydrogen sulfate?

Best regards

Double-Post?

[gerapas]

when we use Tetrabutylammonium Hydroxide or Tetrabutylammonium hydrogen sulfate we do ion pairing?

[HippyLabRat]

when we use Tetrabutylammonium Hydroxide or Tetrabutylammonium hydrogen sulfate we do ion pairing?

In what other case would you want to put that through a column?

[gerapas]

we use TBAHS in prednisolone(which is neutral) assay. we do ion pairing in neutral molecules?