Theoretical Ion Suppression Question
Posted: Wed Jan 23, 2013 10:22 pm
Hi all! I was thinking about ion suppression in my Agilent 6520 QTOF today. I was wondering what factors effect the QUANTITY of ion suppression. Here are some of my thoughts in no particular order:
1. Molecule size
2. Molecule quantity (more of it, more suppression!)
3. Specific atoms in the molecule. Maybe P has a larger affect than N
4. Similar functional groups in the desired molecule vs matrix.
I was wondering if there was any generally known rules about ion suppression. Thanks again!
1. Molecule size
2. Molecule quantity (more of it, more suppression!)
3. Specific atoms in the molecule. Maybe P has a larger affect than N
4. Similar functional groups in the desired molecule vs matrix.
I was wondering if there was any generally known rules about ion suppression. Thanks again!