LOD/LOQ parameter of a method

[anandaraohs]

Hi

My question is regarding LOD and LOQ,

Q-1 : As per the ich guidlines there are 3-4 methods for the determinaton of lod/loq , whether LOD/LOQ calculated by S/N ratio method and other methods like by taking slope and standard deviation is same, if same can it be justified by doing one method (which ever is easier)???

[aceto_81]

You can use whatever method you want, if you can justify!
You don't have to use all of them, just pick one and document which one you used.

Ace