Chromatography Forum

Hello everyone,
I am trying to separate the following structures with TLC. I have tried using 0.4M ammonium sulphate which is regularly used in the lab for TLC. But both the structures run side by side. Can someone please suggest any other solvents I can try. Looking for an educated guess.
Thank you.





p.s. I am not a chemist and don't understand much about chemistry. Therefore your guess is probably much better than mine.

Without knowing what kind of stationary phase is on that plate, and what the Rf values are for your compounds, there is no way to tell.

In general for those compounds, a first guess would be to try adjusting the pH.