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use of triethylamine in HPLC

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use of triethylamine in HPLC

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swarup_80
Triethylamine is used in HPLC , How it interacts with stationary phase so that ,peak shape of compound increases and tailing reduces.

Re: use of triethylamine in HPLC

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tom jupille
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An oversimplified explanation is that it acts as a "competing base" to tie up active silanols. Check out the "chalk talk" on tailing for a more detailed explanation: viewtopic.php?f=31&t=18426
-- Tom Jupille
LC Resources / Separation Science Associates
tjupille@lcresources.com
+ 1 (925) 297-5374
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