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Fronting peaks in GC

Posted: Thu May 12, 2005 12:56 pm
by stanlee
The analyte I'm interested in fronts quite badly.
The compond is a primary amine and I'm running on an RTX amine phase.

Loading seems OK for the column I'm using (30m x .32 x 0.5u) and I think I've got correct flows etc.

Any ideas whats causing this and any tips to try and avoid it ?

TIA

Stanlee

Posted: Thu May 12, 2005 1:42 pm
by chhubert
Fronting may be due to column overloading. Try to inject less or increase the column capacity by increasing the film thickness.

Posted: Thu May 12, 2005 2:38 pm
by Consumer Products Guy
as Stanlee suggests: a good thing to try whenever peak shapes are poor is to inject less sample (injection volume and/or concentration) to see if the shape improves.

fronting

Posted: Thu May 12, 2005 6:52 pm
by chromatographer1
Another common cause for fronting is trying to elute a compound at too low a temperature. The earlier posts I wholeheartedly agree with as well.

peak fronting

Posted: Thu May 26, 2005 8:17 pm
by semivoadude
try setting your initial temp 5 degrees below the boiling point of your solvent.
Ex Mecl2 BP is 40C, Set temp initial at 35C