Analysis of residual sulfolane
Posted: Tue Apr 19, 2005 9:13 am
Hello everybody,
Has anybody analysed residual sulfolane in drugs? I feel this has to be done by extraction method as the boiling point is very high restricting use of headspace technique. I tried to extract using various solvents. I am able to extact fully in chloroform but I find various other peaks all over my chromatogram merging with my Internal std (Dimethylaniline) or anlyte peak. Is there any method to selectively extract sulfolane?
Has anybody analysed residual sulfolane in drugs? I feel this has to be done by extraction method as the boiling point is very high restricting use of headspace technique. I tried to extract using various solvents. I am able to extact fully in chloroform but I find various other peaks all over my chromatogram merging with my Internal std (Dimethylaniline) or anlyte peak. Is there any method to selectively extract sulfolane?