Chromatography Forum

Chromatography Forum is a public discussion group where you can post questions, news, or messages of interest to chromatographers everywhere, but you must be registered to participate (registration is FREE). If you are a registered user, please log in.
http://www.chromforum.org/

Difference between HPLC and LCMS

http://www.chromforum.org/viewtopic.php?t=17359

Page 1 of 1

Difference between HPLC and LCMS

Posted: Fri Aug 05, 2011 5:32 am
by craterw01f
Hi I would like to know the major differences between HPLC and LCMS.
I have to compile a datasheet for the analysis of sildenafil citrate in traditional chinese medicine and my lecturer said that LCMS is suitable for this.

Re: Difference between HPLC and LCMS

Posted: Fri Aug 05, 2011 6:30 pm
by tom jupille
LC-MS is a "hybrid" system in which a mass spectrometer replaces the more usual UV absorbance detector in an HPLC system.

Generally speaking, LC-MS is more specific and (especially in "tandem" LC-MS/MS) more sensitive than standard HPLC. It is also more expensive and complex.
All times are UTC
Page 1 of 1
Powered by phpBB® Forum Software © phpBB Limited
https://www.phpbb.com/