Thermo, Agilent, Bruker, Waters or Applied LC/MS/MS?

[rodrigaoman]

Anyone has any idea if the Bruker Q-TOF MS/MS to be used as LC/MS/MS is useful for ppt quantitative analysis? Any idea of price?


Based on experience and knowlegde, could anyone give me an idea of price and differenteces between Agilent, Applied, thermo and Waters LC/MS/MS (qqq and q-trap)?

I work with drug metabolites quantification in serum, urine and waste water. Most times my analytes are found in pc/mL and ng/mL. Which would be the best cost/bennefit in your oppinions?

Thank you all for the contributions.

[rodrigaoman]

We have a 1200 Varian LC/qqq, but it has poor sensibility and very poor reproducibility of same sample re-injection over 12 hour period.

We do need a new one and we're not sure which one to buy.

[CE Instruments]

Sample type ?
As you currently run a Varian 1200 LC/MS/MS, that is now an Agilent product. I guess you are looking small molecules ? If so maXis Impact is our HR TOF offering , 20-50 times more sensitive for small molecules and will get close to the precision etc. on quantitation of a triple.
The best way to evaluate is call the vendors, prepare a relevant sample and see what we can all do with it