GC MS/MS Manufacturer

[superkidz]

My boss told me to research the specifications of the following equipment:
LC MS/MS
GC MS/MS
GC MS
Orbitraps
ICP MS/MS
Real time PCR

She even instructed that I should go for the  latest models of the above because she wants to know what's the best one. I know that would really depend on the manufacturer and to our intended purpose of use but she just wants the specs of them. I had already emailed the manufacturer but I havent received a reply. Hope you could post some info on this. I also in need of the prices.

One more thing, the IQ/OQ protocol are usually supplied by the supplier in some of our equipment as well as the execution of it  but in most cases, PQ protocol is not supplied. Are we supposed to develop it or we cud purchase it to the manufacturer? Who is supposed to execute it? the manufacturer or it's us? Is PQ and Performance Verification the same? And if not, could we purchase performance verication protocol from the company? Or are there such thing as training for the performance verification and performance qualification by the manufacturer? Thanks!

[giacomo56]

if you are looking for a manufacturer that makes most of those equipments....

Thermo and Agilent come to mind....some of the other equipment manufacturers make some but not all...

[CE Instruments]

As a rep I would not be keen to be responding to this sort of question, it does not indicate any fore knowledge and little intent to buy. You should contact the manufacturers with your analytical requirements looking for them to make instrument suggestions. The best in any catagory will only be the best at a price point and with the right application.

ICP/MS/MS Why ? Surely you mean ICP/MS

Orbitrap, A Thermo proprietary name and product. If you want High resolution analysis FTMS or TOF/TOF ?

PQ is performance qualification, it is entirely dependent on your sample requirements and on going measurement. If you buy an IQ/OQ package you get all you need other than an operator to run the samples and audit the data. This is only usually required in the Pharmaceutical Industry and even then not for all applications. Most manufacturers will happily charge you to develop analytical methods for your samples and to create a suitable PQ protocol.

Bruker can provide you with a solution to fit our outline. Equip yourself with knowledge of what you actually need and can afford and you should get a better response when you contact them (or even me )

[superkidz]

if you are looking for a manufacturer that makes most of those equipments....

Thermo and Agilent come to mind....some of the other equipment manufacturers make some but not all...

tnx for the info. correct me if im wrong but waters has no gc ms/ms? been looking at their website but cant find one. thanks!

[superkidz]

As a rep I wou

PQ is performance qualification, it is entirely dependent on your sample requirements and on going measurement. If you buy an IQ/OQ package you get all you need other than an operator to run the samples and audit the data. This is only usually required in the Pharmaceutical Industry and even then not for all applications. Most manufacturers will happily charge you to develop analytical methods for your samples and to create a suitable
Bruker can provide you with a solution to fit our outline. Equip yourself with knowledge of what you actually need and can afford and you should get a better response when you contact them (or even me )

thanks for the info on PQ. now being cleared, what i mean is if there is such thing as we can determine the performance of the equipment in a holistic approach not by modular like OQ. is the right term for that is performance verification and is it a separate package to buy? tnx!

[JGK]

Some suppliers do offer pre-prepared PQ scripts for your use. However, the important point in regulatory work is that the PQ must be performed in the "intended use" configuration.

Many control systems have a huge list of options with regards to user access audit trails and system configuration etc. These need to be selected and in place prior to PQ testing.

There are third party companies which, for a (substantial) fee, will come in and aid you in the PQ process but, even they, cannot do everything for you if the intended use is in a regilatory setting.

[martsims]

tnx for the info. correct me if im wrong but waters has no gc ms/ms? been looking at their website but cant find one. thanks!

Waters GC-MS/MS is the Quattro Micro GC, is listed under the quadrupole section of their mass spec products on the website. Agilent and Bruker also supply GC-MS/MS instruments (Brukers is the ex-Varian system). Agilent unveiled a GC-QTOF, though this is not available to buy yet.

[Karen01]

tnx for the info. correct me if im wrong but waters has no gc ms/ms? been looking at their website but cant find one. thanks!

Waters GC-MS/MS is the Quattro Micro GC, is listed under the quadrupole section of their mass spec products on the website. Agilent and Bruker also supply GC-MS/MS instruments (Brukers is the ex-Varian system). Agilent unveiled a GC-QTOF, though this is not available to buy yet.

Waters has an APGC (atmosphere pressure GC) ion source (It's essentially Atmospheric Pressure Chemical ionization from what I can tell) that can be connected to a number of it s MS/MS detectors including QTOF

- Karen

[martsims]

So too do Bruker and Agilent. The Bruker source is very much like an LC APCI source, the Waters design is a little more sophisticated with a chamber to constrain the flow from the column and a choice of corona pin positions to force either radical cation or protonated molecule formation. Have not seen the Agilent yet as it is much newer.

[Csaba]

..go for the  latest models of the above because she wants to know what's the best one.

With such a URS, the unserious sales representative will offer the latest and most expensive equipment that propably is NOT suitable for the intended purpuse. You have to write a more complete URS to get a response from the serious sales representatives. If you know what to look for, 1/2 page per instrument type may be enough. Besides Agilent, Bruker, Thermo, Waters, there are Sciex (not GC-MS) and Shimadzu and maybe PerkinElmer.