Specifity Testing

[usallevyn]

I need some help on Specificity Parameter Analysis in Method Validations. How do you demonstrate that there is no interference in the degradation samples. Is it to calculate the % Interference using the raw areas from the blank and actual samples or use the Purity Angles and Purity Thresholds ? What is the best approach? Please advise.
Thanks

[JA]

These might help;

Validation of Impurity Methods, Part I. LCGC America, Jul 2003

Validation of Impurity Methods, Part II. LCGC America, Dec 2003