Separation by GC

[kumaresan]

Which column is good for the seperation of IPA and acetone

[DR]

If you have a good programmable oven and a cold injector port, you could probably do that w/ any packed column (or empty tubing).

[chromatographer1]

Moderate to very polar columns will do the best job on this separation, whether packed or capillary.

Carbowax to a less polar 1701 will separate these two analytes.

There is an amazingly close elution on methyl silicone and porous polymers, isn't there?

best wishes,

Rod

[WK]

Do not use a 624 since they nearly co-elute or only just resolve (even though its good for solvents generally).
WK

[chromatographer1]

That is correct, a 3% cyanopropyl 3% Phenyl methyl silicone (624 aka 1301) is less polar than the 1701 (7% cyanopropyl 7% phenyl methyl silicone), but anything more polar should be fine for the separation of acetone and isopropanol.

[Ron]

You might also want to consider using a PLOT column. I got some very good separations of polar solvents on a PLOT-Q column a few years back, although I don't remember if your two analytes were in the mix.

[jtoxx]

I have seen haysep s , carbowax , poropak work also several cap columns such as RTX BAC1, RTX BAC 2, and RTX 200.

[MikeD]

My records show (approx) Kovat indices:
on non-polar silicone - acetone 487, isopropanol 488
on OV1701 equivalent - acetone 589, isopropanol 601.
These were measured with temperature programming so the correspondence with the literature won't be too good, but it's an indication.

[chromatographer1]

Supelco's Equity 1701 will separate acetone and IPA at 40°C very cleanly, even when dissolved into water. More polar columns should also separate these two analytes.