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Alprazolam and Clonazepam in Urine
Posted: Thu Feb 24, 2011 12:40 pm
by polarbear
I am searching for an extraction procedure recommended for identification and quantification of Alprazolam and Clonazepam and/or its metabolites in urine sample using a Thermo TSQ Quantum Acess Max LC-MS/MS or LC-MS system. Many thanks!
Re: Alprazolam and Clonazepam in Urine
Posted: Thu Mar 03, 2011 7:13 pm
by X
I recommend DAU column from UCT, very good SPE column.
Re: Alprazolam and Clonazepam in Urine
Posted: Sun Jun 05, 2011 12:21 pm
by che313
if u r looking for those compounds only adjust ur sample ph to 8-9 and ectract t with ethyl acetate. but if u r looking for thier metabolites u'll need to hydrolyse ur sample with beta-glucuronidase then extract t by lle or spe.
Re: Alprazolam and Clonazepam in Urine
Posted: Tue Aug 02, 2011 10:10 pm
by serifermis
For dedecting 7 aminoclonazepam and a-hydroxyalprazolam,
B-glucuronidase hydrolysis
UCTmark BNZ SPE column extraction
even dedect with LC-DAD