System suitability

[Basil]

Which criteria do you use to define the system suitability test for intermediates in a synthetic route for an API ?.....

Should be the same as the product ?..

Thanks

[tom jupille]

Same kind of specs (retention windows for compounds of interest, resolution between critical pairs, plus the usual repeatability, pressure, etc.) but appropriate to the compound for which you are analyzing.

[JA]

Tom,
do you record pressure only for potential troubleshooting? Also what in particular would you note when using a gradient - the initial pressure prior to an injection, maximum over an injection?

[tom jupille]

Yes, primarily for troubleshooting. Probably the initial pressure would be the easiest/most relevant as an indicator of column problems.