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I personally would NEVER use a cyano column for prep applications. First, cyano ligands hydrolyze much easier than C18 ligands, second, cyano columns tend to be unstable (as Bruce has seen), and third, I expect the loadability to be much lower than that of a C18....
...My advise... is to get the literature from the manufacturers that are worth considering, and then COMPARE their products based on the described features, such as column stability and preparative loadability. Since prepartive columns are expensive, you want to make sure that you get your money's worth.
To second rwang's post...
From Uwe Neue in a previous Chromforum discussion:
viewtopic.php?t=11206&sid=bc5eca77f9127 ... 59e44d38ca
I personally would NEVER use a cyano column for prep applications. First, cyano ligands hydrolyze much easier than C18 ligands, second, cyano columns tend to be unstable (as Bruce has seen), and third, I expect the loadability to be much lower than that of a C18....
...My advise... is to get the literature from the manufacturers that are worth considering, and then COMPARE their products based on the described features, such as column stability and preparative loadability. Since prepartive columns are expensive, you want to make sure that you get your money's worth.