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Sulfuric acid in mobile phase with ELSD?

http://www.chromforum.org/viewtopic.php?t=11883

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Sulfuric acid in mobile phase with ELSD?

Posted: Fri Dec 11, 2009 1:50 pm
by avitan
Hello,

Can one use very diluted sulfuric acid solution with ELSD?

Posted: Fri Dec 11, 2009 3:38 pm
by ihenderson
ELSD can not be used with mobile phase modifiers that are not volatile at the temperature selected for operation. Some modifiers are volatile and can be used. These include but are not limited to acetic acid, trifluoroacetic acid (TFA), formic acid, triethylamine, and ammonia. For the best sensitivity, the concentration of buffer in the mobile phase should be as low as possible and of the highest quality.

Posted: Fri Dec 11, 2009 5:02 pm
by JGK
This might be useful
http://chromatographyonline.findanalyti ... rticle.pdf
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