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Have you ever known the DRYLAB?
Posted: Tue Jun 30, 2009 2:32 am
by weeker2001
i am reading the bookmethos validation in pharmaceutical analysis .and in the robustness testing .it refers that we could use the computer-assisted robustness studies .such as drylab ,chromsword ,and design of experiments (modde ,minitab,statgraphics )
could i use the software drylab in my paper of devlopment of hplc method?
have you ever known it ,and used it ?
Posted: Wed Jul 01, 2009 1:08 pm
by tom jupille
It is used fairly extensively in pharmaceutical HPLC method development. You can get more information at:
http://www.molnar-institut.com/cd/indexe.htm
By way of "full disclosure", for many years I did support and training for DryLab.
Posted: Wed Jul 01, 2009 6:13 pm
by MTS
I can add an impartial opinion. I have used DryLab extensively to develop methods for pharmaceuticals and have found it to be extremely useful. The model that you create in the DryLab software for your method development also provides good robustness data for method validation.
Posted: Fri Jul 03, 2009 11:22 pm
by Alfred88
DryLab has been described in detail in LLoyd Snyder's book "Practical HPLC Method Development." (more than >10 yrs ago). Other tools described in Chapter 10 of that book are: ICOS (HP), Diamond (ATI), PESOS, Eluex, Chromdream, HPLC-Metabolexpert, ProDigest-LC.
You may want to consider Fusion AE offered by Varian. This latest tool can help to do full-factorial design for method development/optimization/validation/reporting.
It may not be economical to buy DryLab or Fusion (or others), if you don't do development every few months.
Disclaimer: I don't sell any software mentioned here, and do not work for Varian.
Posted: Wed Jul 08, 2009 6:36 am
by Anthony_Ng
It may not be economical to buy DryLab or Fusion (or others), if you don't do development every few months.
May I know the approx. price (range) for DryLab? Is there any DryLab version for GC?
Are there any demo/evaluation version to get a first insight about this? (Hence I can have more bargaining power to convice my boss to purchase it)
Thanks a lot!
Posted: Wed Jul 08, 2009 9:18 am
by aceto_81
It may not be economical to buy DryLab or Fusion (or others), if you don't do development every few months.
May I know the approx. price (range) for DryLab? Is there any DryLab version for GC?
Are there any demo/evaluation version to get a first insight about this? (Hence I can have more bargaining power to convice my boss to purchase it)
Thanks a lot!
Posted: Thu Jul 09, 2009 1:27 am
by tom jupille
DryLab does have a GC mode. As far as price and demos, you should contact the supplier, Molnar-Institut:
http://www.molnar-institute.com/HP/Software/DryLab.php
Posted: Thu Jul 09, 2009 9:07 am
by Koen Hollebekkers
I think the automation part greatly improved the practical use of Drylab
Posted: Fri Jul 10, 2009 12:35 am
by Alfred88
Dear Anthony_Ng:
You need to bugdet for >12K.
It is understood that you will need to buy a kit for method development. Usually, a kit may contain 5-6 columns of different phases. Yes, modern chromatography still required trial, scouting/exploring runs.
Check out the white paper for Fusion AE for method development, validation, and case study here:
http://www.scribd.com/doc/17243086/Fusi ... Whitepaper
and here:
http://www.scribd.com/doc/17243099/Fusi ... Whitepaper
And the approach is for small molecules only.
Posted: Fri Jul 10, 2009 6:17 am
by aceto_81
about FusionAE: take a look at this topic:
viewtopic.php?t=10348
Drylab is expensive, but it saved us lots of time.