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spiky, hairy noisy TIC chromatogram

http://www.chromforum.org/viewtopic.php?t=10469

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spiky, hairy noisy TIC chromatogram

Posted: Thu Apr 23, 2009 12:42 pm
by moonchips
Greetings.

We have a Waters LC-MS.
The regular chromatogram has a perfect smooth baseline, but the TIC chromatogram is very noisy.

What could be the reason of this problem?

Thanks a lot in advance!

Posted: Fri Apr 24, 2009 3:44 pm
by moonchips
We figured it out.
We used methanol, 25 mM ammonium acetate as mobile phase.

We changed it to 10 mm ammonium acetate. the problem it gone.

thanks
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