Chromatography Forum

I wanted to add something to this discussion.

I hope it's ok, I've referenced information from brochure below:
http://www.mac-mod.com/pb/halo-pb.html

Fused Core (2.7um) ODS
Support: Ultra-pure, "Type B" Silica
Support: 1.7um solid core particle with a 0.5um porous silica layer fused to the surface
surface area: 150m2/g
Pore size: 9 nm
Bonding: Monomeric (ODS), densely bonded phase
Endcapping: Maximized endcapping

Cadenza CW-C18
Support: High purity 3um porous silica
Surface area: c.a. 100m2/g
Pore size: 30 nm
Bonding: Polyfunctional ODS
Endcapping: Polymeric endcapping

Cadenza CW-C18 is a different design concept (3um particle, less surface area,
different bonding / endcapping) than Fused Core (2.7um) ODS. However, both have less
surface area than conventional ODS phases. This results in faster elution
for small molecule analysis (high throughput).
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Below is LC-MS application for phospholipids on Cadenza CW-C18 and Fused Core (2.7um) ODS:
http://www.imtakt.com/TecInfo/TI477E.pdf

The phospholipids show faster elution on Cadenza CW-C18 (which may contribute to the
difference in sensitivity).

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Fused Core (2.7um) ODS technlogy can be used for HT analysis of small molecules.
Another option is Imtakt's wide-pore technology (Cadenza CW-C18, 3um, 30nm pore size).


Thanks!