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Discussions about HPLC, CE, TLC, SFC, and other "liquid phase" separation techniques.

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problem resolved

Even if there is an intrinsic difference in noise, it may not be a problem in practice. My suggestion is to carefully consider the settings for the sampling rate / detector time constant, and - most of all - to try it out after this has been optimized. You can easily get a significant noise reduction with such tricks.
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