HILIC (Merck) or HILIC (Phenomenex) Who is the best ?

[JOCAPEN]

Please, Could you tell me more information about your experience for this kind of column ?

Tanks a lot

[tom jupille]

I suspect there is no universal "best". Selectivity is arguably the most important parameter in any LC separation, and favorable selectivity for one application can be unfavorable for another. As with reversed-phase, HILIC selectivity is significantly affected by secondary interactions.

[Uwe Neue]

Well the reason for the question is not clear, nor is the context. I think Phenomenex has several HILIC phases. I don't know what Merck has, but there are a lot of different manufacturers around that have HILIC phases, some with known and demonstrated reproducibility and stability.

[Bruce Hamilton]

Well the reason for the question is not clear, nor is the context. I think Phenomenex has several HILIC phases. I don't know what Merck has,....

SeQuant ( ZIC-HILIC ) = Merck.
Phenomenenx seem to promote their Luna HILIC, which I think may be a Diol phase.

Any comments about the merits/demerits of Diol-based columns for HILIC?. I think the Phenomenex Luna HILIC is an ethylene-bridged cross-linked Diol phase on silica.

Bruce Hamilton

[zlb215]

How about Waters' HILIC?

[Bryan Evans]

What type of compounds are you trying to separate?