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Solvent for NPD
Posted: Wed Aug 14, 2019 5:15 am
by push
I am planning to use GC with NPD for phosphorus containing compound. Which solvents are recommended to dissolve compounds? Can they contain "O", "Cl", "N"?
Re: Solvent for NPD
Posted: Wed Sep 04, 2019 2:50 pm
by AICMM
Push,
Don't recommend CL. Do recommend turning off power for solvent elution. Really recommend you get a hold of Paul Patterson at DET (det-gc dot com)
The GURU of that detector.
Best regards,
AICMM
Re: Solvent for NPD
Posted: Thu Sep 05, 2019 8:40 pm
by James_Ball
Definitely don't want a nitrogen containing solvent like pyridine since the detector is sensitive to nitrogen, that would give a massive solvent peak.
I know hexane and MTBE are used when doing NP pesticides by the EPA methods though.
Re: Solvent for NPD
Posted: Wed Oct 16, 2019 1:43 pm
by MSCHemist
For that matter you might want to avoid a GC column with nitrogen in the stationary phase like 1701, 624 (cyanopropyl side chains). Otherwise any non nitrogen solvent is probably fine.
I like
acetone (one of my favorites it dissolves almost anything)
toluene (for higher boilers also has broad solubility)
heptane
diethyl ether (I try to avoid due to risk of peroxide formation)
ethyl acetate
methanol
ethanol
isopropanol