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Peak purity(impurity having same spectra)

http://www.chromforum.org/viewtopic.php?t=9810

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Peak purity(impurity having same spectra)

Posted: Sat Dec 27, 2008 12:28 pm
by ajey
Dear all,
If impurity peak has a same spectra with analyte peak and it is coeluting with analyte peak, then how will we come to know that there is impurrity merging or how can we detect that impurity?
Regards,
Ajay

Posted: Sat Dec 27, 2008 3:12 pm
by HW Mueller
A considerably different chromatographic method, and/or entirely different analytical tool (MS, NMR, IR, melting points, carbon hydrogen analysis . . . .) might show this.

Posted: Thu Feb 19, 2009 10:11 am
by tangaloomaflyer
If an impurity has exactly the same spctra then you would need a new separation technique, but if they have similar spectra the key to differentiating them is to have more data points across a peak by using an instrument with a high scan rate and deconvolution software
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