Aglient M/S Scan Speed

[isuphysics]

We have Aglient 6130 M/S, the scan speed can only go up 2500 u/sec (standard mode) & 5250 u/sec (fast mode), I have seen other M/S which can go higher, like Shimadzu LC/MS 2010EV, which I was told goes up to 6000 amu/sec. What are the advantages of having a higher scan speed?

[thohry]

In case you have very fast peak elution like in GC, high scan speed is important.

[sindhu]

scan speed is only applicable to full scan qualitative experiments
like a Q1, Product Ion, Precursor Ion, and Neutral Loss scan where
the quadrupole is set to scan over a range of masses in a set period
of time in order to determine what compounds may be present in the unknown sample.

However, when performing a MRM experiment for targeted quantitation where Q1 and Q3 are set to filter specific ions as they pass through the ion optics, it is the dwell and the pause times and the number of MRM transitions monitored that determine the cycle time and thus the number of data points obtained across a given HPLC peak.

Hence depending on your application ( its only scan or MRM ) you can decide on the scan speed function of a system