Dissolution solvent for mPEG-propionaldehyde
Posted: Thu Oct 09, 2008 4:15 pm
I am trying to determine residual solvents in mPEG-propionaldehyde. I am currently using a DB-624 column with an Agilent 7890A GC and G1888 headspace. I am looking for mostly class II (methanol, toluene, methylene chloride)solvents and then some class III. (ethyl acetate, tert-methylbutyl ether).
I tried using DMSO as the dissolution solvent, but had extra peaks due to reactions with the mPEG-propionaldehyde.
I also have used DMF, but I keep finding an odd peak (even with different brands) that may be due to ineractions although I am not sure what they would be.
I am wondering what would be the best solvent to try now. Anyone have some good ideas?
I tried using DMSO as the dissolution solvent, but had extra peaks due to reactions with the mPEG-propionaldehyde.
I also have used DMF, but I keep finding an odd peak (even with different brands) that may be due to ineractions although I am not sure what they would be.
I am wondering what would be the best solvent to try now. Anyone have some good ideas?