Chromatography Forum

I am doing work on FMOC and I like to know whether FMOC can react with carboxylic acid functional group
Thanks

Are you using it on amino acids? Under the common conditions that I have used it reacted with the amino group, NH3 (which always seems to be present), and H2O. If there was an appreciable (or any) reaction with the carboxyl group it would not be used to derivatize amino acids. It should be understood that the reaction with H2O is quite slow, relatively, but due to the high concentration of H2O the reaction is easily seen.

I believe organic reaction depends on conditions, competitions, reagents, solvents, time etc