Chromatography Forum

hello All,

There are some columns that can tolerate direct injection of aqueous sample and related papers were frequently published. however, Most of this kind of method was using GC-FID. i.e FID as an sole detector. I just wonder whether GC-MS can be used to direct injection of aqueous sample? If not, do you have any idea about the limit of water content in sample for Gc-Ms analysis?


Thanks advance

hello All,

There are some columns that can tolerate direct injection of aqueous sample and related papers were frequently published. however, Most of this kind of method was using GC-FID. i.e FID as an sole detector. I just wonder whether GC-MS can be used to direct injection of aqueous sample? If not, do you have any idea about the limit of water content in sample for Gc-Ms analysis?


Thanks advance

No, Water ionizes in the source very easily and has a nasty habit of reacting with pretty much anything else in your sample. Keeping total water content under 1% is a good idea.

s2008,

Water also takes a long time to pump out of the vacuum system which is why a pumpdown is often more about getting water under control than it is about getting rid of all the air.

Yech.

Best regards.