ascorbic acid

[Mohamad]

Hello guys,
can someone help me about ran ascorbic acid on GC

[rb6banjo]

It'll never work. I'd find another way to do it. Firstly, the boiling point is way too high. There are other problems but this is the big one.

[Consumer Products Guy]

Hello guys,
can someone help me about ran ascorbic acid on GC

Wrong "tool". Would you brush your teeth with a wrench?

[Mohamad]

thank you for reply. but i have COA from different vendors and all them have GC test and that is the reason make me try to find if there is a method to ran ascorbic acid on GC.

[Consumer Products Guy]

So contact those suppliers, suppliers will often share QC methods, some can be adapted for use in finished products. But likely GC was used for stuff like residual solvents, etc.

[BMU_VMW]

What would you like to know about your acid?

e.g. if you want to check for volatile contaminants than headspace sampling of a vial of ascorbic acid should be possible.

[MSCHemist]

I believe I tried some derivatization methods (ethyl chloroformate) etc haven't found one that worked well. I think silylation may but you definitely need to derivatize as I believe ascorbic has both too high a boiling point and is not thermally stable.

Edit yep silylation with HMDS in acetonitrile.
https://www.sciencedirect.com/science/a ... 3503001919
the complication being it has to be lyophilized because normal evaporation under heat/nitrogen degrades it.

I have a request for it now and I am looking into UV-VIS assays.