unstable peptide
Posted: Wed Aug 06, 2008 1:40 pm
Dear all,
I am dealing with a cyclic lipo-(hexa) peptide (antifungal agent). Unlike similar compounds, it is unstable in aqueous solutions and plasma (half-life around 8 hours at room temperature and neutral pH). Is there any additive that may stabilize the peptide bonds?
Thank you for help.
Friederike
I am dealing with a cyclic lipo-(hexa) peptide (antifungal agent). Unlike similar compounds, it is unstable in aqueous solutions and plasma (half-life around 8 hours at room temperature and neutral pH). Is there any additive that may stabilize the peptide bonds?
Thank you for help.
Friederike